Research Projects Supported by PICU

SAFE-EPIC STUDY — The SAFE Extrapolation to Paediatric Intensive Care

An international point prevalence study of fluid resuscitation practice in paediatric intensive care. 

Objectives

 

To document current practice in fluid resuscitation in PICU patients. 

Design

Point prevalence on two study days with 28 day outcome data

Duration

2012-13- DATA COLLECTION COMPLETED

Sample size

 

2100 patients aged 0-16years in paediatric intensive care units worldwide (37 countries). 

Chief Investigator

Dr Marino Festa, Sydney Australia

Local Principle Investigator

Dr Richard Levin, PICU Consultant

Local Study Co-ordinator

Isobel Macleod, PICU Audit and Research Nurse

           

SPROUT STUDY—Sepsis Prevalence, OUtcomes and Therapy

An international point prevalence study of paediatric severe sepsis and septic shock

Objectives

 

To characterise critically ill children with sepsis, including variability in treatment and patient-centred outcomes 

Design

Point prevalence on five study days      

Duration

Duration: June 2013-June 2014- DATA COLLECTION COMPLETED

Sample size

 

2700+ patients aged 0-17years from more than 50 PICUs worldwide (~30 countries). 

Chief Investigator

Dr Scott Weiss, CHOP, USA

Local Principle Investigator

Dr Richard Levin, PICU Consultant

Local Study Co-ordinator

Isobel Macleod, PICU Audit and Research Nurse

 

PLASMA-TV/SEPT-UK – Point Prevalence Study of Plasma Transfusion Exposure

An international point prevalence study of plasma transfusion in paediatric intensive care. 

Objectives

 

To identify patient characteristics and clinical conditions leading to plasma transfusion in critically ill children, to assess effect of plasma transfusion on coagulation tests and to assess the outcome after plasma transfusions 

Design

Point prevalence for 6 weeks over a 6 month period

Duration

2014-DATA COLLECTION COMPLETED OCT14

Sample size

 

112 PICUs from 22 countries.  Aim: 339 patients receiving plasma transfusions

Chief Investigator

Dr Oliver Karam, Switzerland.

Local Principle Investigator

Dr Richard Levin, PICU Consultant

Local Study Co-ordinator

Isobel Macleod, PICU Audit and Research Nurse

 

RIPC STUDY— Remote Ischaemic Preconditioning

A prospective interventional study to examine the effect of remote ischaemic preconditioning in cardiac dysfunction and end-organ injury following cardiac surgery with cardiopulmonary bypass in children.  A translational approach investigating clinical outcome and myocardial molecular biology. 

Design

Randomised Control Trial          

Duration

2012-2014

Sample size

80 patients undergoing cardiopulmonary bypass surgery

Chief Investigator

Mr Mark Danton, Cardiac Surgeon.

Local Principle Investigator

Maribel Verdesoto (PhD student)

Co-Investigator/Collaborators

Dr Neil Spenceley, PICU Consultant.

Prof Fiona Lyall, University of Glasgow

Dr David Young, Statistician

Dr Dawn Penman, Pathologist

Local Study Co-ordinator

Dr Neil Spenceley PICU

Funding

Yorkhill Children’s Charity PhD Studentship

 

Pro-inflammatory Lung Dendritic Cells in Stratified Severe RSV Bronchiolitis

A multi-centred prospective interventional study to examine activated lung conventional dendritic cells in infants with severe prolonged RSV bronchiolitis. 

Design

Prospective multi-centred study

Duration

2012-2015

Sample size

 

Infants <18months old="" born="">32 weeks gestation, admitted to PICU & requiring ventilation due to viral bronchiolitis local recruitment target 20 patients per winter plus controls.

Chief Investigator

Prof J. Schwartz, Edinburgh

Local Principle Investigator

 

Dr Richard Levin, PICU Consultant.

Local Study Co-ordinator

CRF Nurses-SSN Liz Waxman

Funding

Medical Research Council (MRC) Grant

 

Weight Prediction Study

A study to develop and cross validate a new weight prediction equation for use in acute and critical care settings.

Design

A prospective cohort study

Duration

2012-2014

Sample size

50 PICU patients and 600 A&E patients

Chief Investigator

Dr Neil Spenceley, PICU Consultant

Local Principle Investigator

Dr Neil Spenceley, PICU Consultant

Co-Investigators

Dr Konstantinos Gerasimidis, University of Glasgow

Dr Vincent Choundray, A&E Consultant

 

 

MC5-Study  Micronutrients in Children in Critical Care with Cardiac Conditions Study

A single-centred study to assess the type, frequency and associates of micronutrient deficiencies in infants/children with congenital cardiac disease admitted for surgery. 

Design

Proof of concept prospective interventional study

Duration

2014-2016

Sample size

50 patients

Chief Investigator

Dr Neil Spenceley PICU

Local Principle Investigator

Dr Neil Spenceley PICU

Co-Investigator/Collaborators

Dr Neil Spenceley, PICU Consultant.

Dr Konstantinos Gerasimidis, University of Glasgow

Mrs Jackie Mara, Dietitian

Mrs Emma Gentles, Dietitian

Dr Andrew Duncan, Clinical Biochemist

Dr Dinesh Talwar, Clinical Biochemist

Mr Mark Danton, Cardiac Surgeon

Dr Robert Ghent, Cardiac Anaethetist

Funding

Yorkhill Children’s CharitySmall Project Grant

 

Selection, definition and evaluation of important early morbidities associated with paediatric cardiac surgery

A multi-centred study to identify surgical morbidities that present the greatest burden on patients and health services and to develop and pilot routine monitoring and feedback these key morbidities

Design

Prospective Study

Duration

2015-2017

Sample size

3000-3300 patients across 5 UK cardiac centres

Chief Investigator

Mr Victor Tsang, Cardiac Surgeon, GOSH

Local Principle Investigator

Dr Warren Rodrigues, Paediatric Intensivist

Local Co-Investigator/Collaborators

Mr Andrew McLean, Cardiac Surgeon

Isobel Macleod, PICU Audit and Research Nurse

Funding

NIHR Grant

Research Projects Involving PICU Patients, supported from other Services

The Assessment of Long Chain Fat Intakes during the Management of Paediatric Chylothorax

A study to review diet therapy of all paediatric congenital heart patients diagnosed with chylothorax.   To ascertain, through prospective analysis, LCT intakes of all patients diagnosed with chylothorax during their dietary therapy and compare against current dietary recommendations. 

Design

A multi centred prospective cohort pilot observational study

Duration

2012 (6 months)

Sample size

70 patients across 10 UK/ROI centres

Chief Investigator

Phillippa Wright, Royal Brompton Hospital, London

Local Principle Investigator

Laura Flannagan, Dietitian