Research Projects Previously Supported by PICU

SAFE-EPIC STUDY — The SAFE Extrapolation to Paediatric Intensive Care
An international point prevalence study of fluid resuscitation practice in paediatric intensive care.
Objectives	To document current practice in fluid resuscitation in PICU patients.
Design	Point prevalence on two study days with 28 day outcome data
Duration	2012-13- DATA COLLECTION COMPLETED
Sample size	2100 patients aged 0-16years in paediatric intensive care units worldwide (37 countries).
Chief Investigator	Dr Marino Festa, Sydney Australia
Local Principle Investigator	Dr Richard Levin, PICU Consultant
Local Study Co-ordinator	Isobel Macleod, PICU Audit and Research Nurse

SPROUT STUDY—Sepsis Prevalence, OUtcomes and Therapy
An international point prevalence study of paediatric severe sepsis and septic shock
Objectives	To characterise critically ill children with sepsis, including variability in treatment and patient-centred outcomes
Design	Point prevalence on five study days
Duration	Duration: June 2013-June 2014- DATA COLLECTION COMPLETED
Sample size	2700+ patients aged 0-17years from more than 50 PICUs worldwide (~30 countries).
Chief Investigator	Dr Scott Weiss, CHOP, USA
Local Principle Investigator	Dr Richard Levin, PICU Consultant
Local Study Co-ordinator	Isobel Macleod, PICU Audit and Research Nurse

PLASMA-TV/SEPT-UK – Point Prevalence Study of Plasma Transfusion Exposure
An international point prevalence study of plasma transfusion in paediatric intensive care.
Objectives	To identify patient characteristics and clinical conditions leading to plasma transfusion in critically ill children, to assess effect of plasma transfusion on coagulation tests and to assess the outcome after plasma transfusions
Design	Point prevalence for 6 weeks over a 6 month period
Duration	2014-DATA COLLECTION COMPLETED OCT14
Sample size	112 PICUs from 22 countries. Aim: 339 patients receiving plasma transfusions
Chief Investigator	Dr Oliver Karam, Switzerland.
Local Principle Investigator	Dr Richard Levin, PICU Consultant
Local Study Co-ordinator	Isobel Macleod, PICU Audit and Research Nurse

RIPC STUDY— Remote Ischaemic Preconditioning
A prospective interventional study to examine the effect of remote ischaemic preconditioning in cardiac dysfunction and end-organ injury following cardiac surgery with cardiopulmonary bypass in children. A translational approach investigating clinical outcome and myocardial molecular biology.
Design	Randomised Control Trial
Duration	2012-2014
Sample size	80 patients undergoing cardiopulmonary bypass surgery
Chief Investigator	Mr Mark Danton, Cardiac Surgeon.
Local Principle Investigator	Maribel Verdesoto (PhD student)
Co-Investigator/Collaborators	Dr Neil Spenceley, PICU Consultant. Prof Fiona Lyall, University of Glasgow Dr David Young, Statistician Dr Dawn Penman, Pathologist
Local Study Co-ordinator	Dr Neil Spenceley PICU
Funding	Yorkhill Children’s Charity PhD Studentship

Pro-inflammatory Lung Dendritic Cells in Stratified Severe RSV Bronchiolitis
A multi-centred prospective interventional study to examine activated lung conventional dendritic cells in infants with severe prolonged RSV bronchiolitis.
Design	Prospective multi-centred study
Duration	2012-2015
Sample size	Infants <18months old="" born="">32 weeks gestation, admitted to PICU & requiring ventilation due to viral bronchiolitis local recruitment target 20 patients per winter plus controls.
Chief Investigator	Prof J. Schwartz, Edinburgh
Local Principle Investigator	Dr Richard Levin, PICU Consultant.
Local Study Co-ordinator	CRF Nurses-SSN Liz Waxman
Funding	Medical Research Council (MRC) Grant

Weight Prediction Study
A study to develop and cross validate a new weight prediction equation for use in acute and critical care settings.
Design	A prospective cohort study
Duration	2012-2014
Sample size	50 PICU patients and 600 A&E patients
Chief Investigator	Dr Neil Spenceley, PICU Consultant
Local Principle Investigator	Dr Neil Spenceley, PICU Consultant
Co-Investigators	Dr Konstantinos Gerasimidis, University of Glasgow Dr Vincent Choundray, A&E Consultant

MC5-Study Micronutrients in Children in Critical Care with Cardiac Conditions Study
A single-centred study to assess the type, frequency and associates of micronutrient deficiencies in infants/children with congenital cardiac disease admitted for surgery.
Design	Proof of concept prospective interventional study
Duration	2014-2016
Sample size	50 patients
Chief Investigator	Dr Neil Spenceley PICU
Local Principle Investigator	Dr Neil Spenceley PICU
Co-Investigator/Collaborators	Dr Neil Spenceley, PICU Consultant. Dr Konstantinos Gerasimidis, University of Glasgow Mrs Jackie Mara, Dietitian Mrs Emma Gentles, Dietitian Dr Andrew Duncan, Clinical Biochemist Dr Dinesh Talwar, Clinical Biochemist Mr Mark Danton, Cardiac Surgeon Dr Robert Ghent, Cardiac Anaethetist
Funding	Yorkhill Children’s CharitySmall Project Grant

Selection, definition and evaluation of important early morbidities associated with paediatric cardiac surgery
A multi-centred study to identify surgical morbidities that present the greatest burden on patients and health services and to develop and pilot routine monitoring and feedback these key morbidities
Design	Prospective Study
Duration	2015-2017
Sample size	3000-3300 patients across 5 UK cardiac centres
Chief Investigator	Mr Victor Tsang, Cardiac Surgeon, GOSH
Local Principle Investigator	Dr Warren Rodrigues, Paediatric Intensivist
Local Co-Investigator/Collaborators	Mr Andrew McLean, Cardiac Surgeon Isobel Macleod, PICU Audit and Research Nurse
Funding	NIHR Grant

Research Projects Involving PICU Patients, supported from other Services

The Assessment of Long Chain Fat Intakes during the Management of Paediatric Chylothorax
A study to review diet therapy of all paediatric congenital heart patients diagnosed with chylothorax. To ascertain, through prospective analysis, LCT intakes of all patients diagnosed with chylothorax during their dietary therapy and compare against current dietary recommendations.
Design	A multi centred prospective cohort pilot observational study
Duration	2012 (6 months)
Sample size	70 patients across 10 UK/ROI centres
Chief Investigator	Phillippa Wright, Royal Brompton Hospital, London
Local Principle Investigator	Laura Flannagan, Dietitian